Gamblers seldom come forward voluntarily to be treated for gambling addiction. In some cases, hospitalization may help by removing an individual from his or her gambling environment. Gamblers Anonymous, modeled on Alcoholics Anonymous, is an effective treatment for some individuals.

Insight-oriented psychotherapy can also be effective after an individual has stopped gambling for 3 months.

Pharmacological treatment is also effective in helping to manage gambling disorder. Effective medications include antidepressants, notably selective serotonin reuptake inhibitors (SSRIs) and bupropion (Wellbutrin, Zyban); mood stabilizers, including sustained-release lithium (Eskalith) and antiepileptics such as topiramate (Topamax); atypical antipsychotics; and opioid agents such as naltrexone (ReVia).